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KMID : 0361720120230020069
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Korean Journal of perinatology
2012 Volume.23 No. 2 p.69 ~ p.75
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Effect of Initial Empirical Antibiotics Duration on Neonatal Outcomes in Very Low Birth Weight Infants
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Bak Nu-Ri
Kim Myo-Jing
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Abstract
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Purpose: Little is known about the duration of antibiotics for suspected early-onset sepsis (EOS) with negative blood cultures. The purpose of this study is to identify associations between the duration of empirical antibiotics and neonatal outcomes.
Methods: We retrospectively reviewed medical records of very low birth weight infants (VLBW) who admitted to NICU in 2007-2010. We defined empirical antibiotic therapy group as those who started antibiotic therapy in first 3 postnatal days. We compared the neonatal outcomes between short empirical antibiotic therapy (<5 days) and long empirical antibiotic therapy (> or =5 days).
Results: Of 122 VLBW, 72 infants were long empirical antibiotic therapy group. In the long empirical antibiotic therapy group, there were lower birth weight, higher rate of out-born, higher rate of vaginal delivery, and had lower Apgar scores. Prolonged antibiotic therapy was associated with delayed start of enteral feeding and incidence of ESBL.
Conclusion: Prolonged antibiotic therapy may be associated with some adverse neonatal outcomes. Therefore, wide spread agreement regarding the short empirical antibiotic therapy was needed.
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KEYWORD
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Antibiotics, Infant, very low birth weight, Outcomes
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